This seems like an important point for understanding Manaus. If your blood donor samples consist of people who suspected they probably had COVID and wanted a result, you may overestimate seroprevalence significantly, leaving room for a spike in a population that felt protected? https://twitter.com/WesPegden/status/1349924706586124294
Imagine you are pretty sure you had COVID in September but couldn't get a test, and a seroprevalence study is taking place offering you the answer for free if you donate blood. Would you be more inclined to step forward to donate? So, big if true.
Obviously an ongoing debate, here a nice thread from Bill Hanage with some useful links. https://twitter.com/BillHanage/status/1349943613514526723?s=20
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