Ever wonder how specific genome maintenance factors are sumoylated at DNA replication and repair sites to modulate their functions? 1/4
Our new work by @Shibai6 and @Jakebonnbonn at @ZhaoLab_SKI @sloan_kettering, @WeillCornellGS #BCMB in collaboration with Xiaoyu Xue’s Lab @txst provides insight. Congrats to all authors for their tireless efforts the past several years. 2/4
Using budding yeast as a model system, we found that Esc2 can act as a SUMO E2 cofactor at distinct DNA structures to promote the sumoylation of specific substrates and genome maintenance. More details can be found @GenesDev http://genesdev.cshlp.org/content/early/2021/01/12/gad.344739.120.full.pdf+html 3/4
We hope this work will stimulate studies of sumoylation mechanisms and mammalian Esc2 homologs that are important for genome maintenance. 4/4
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