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Thread that I try to start/engage every so often: post your favorite RCT's with something "interesting" (good, bad, or just weird) about them. Anything related to design, conduct, analysis, or interpretation that makes it "interesting" is welcome. A few random examples:
1. the PEPTIC trial is an interesting example of a cluster-crossover design where ICU's were assigned to use one intervention for 6 months, then the other intervention for 6 months. https://pubmed.ncbi.nlm.nih.gov/31950977/
2. A bit older, but the BARI 2D trial is a neat example of a 2x2 factorial trial as well as assignment to "strategies" for the randomization rather than specific drugs or devices: https://pubmed.ncbi.nlm.nih.gov/19502645/
3. the DAWN trial is a favorite of mine for introducing the concept of adaptive trials in a relatively gentle, digestible way: https://pubmed.ncbi.nlm.nih.gov/29129157/
4. the PHANTASi trial is a good cautionary tale of the importance of making sure everyone is really on board with randomization...
(in this open-label trial EMS personnel were found to be opening envelopes until they got one for the intervention group) https://pubmed.ncbi.nlm.nih.gov/29196046/
(in this open-label trial EMS personnel were found to be opening envelopes until they got one for the intervention group) https://pubmed.ncbi.nlm.nih.gov/29196046/
Feel free to throw your favorites up here, or if you want to ask if anyone has ever seen a particular thing proposed or happen in practice, I'll put up the bat signal & maybe one will emerge.
