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Have you read Gualano 2010:
“Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial.”
“Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial.”
Why consider #creatine and diabetes?
Creatine has shown benefits in:
Insulin resistance
Enhancements in insulin sensitivity
Improvements in glucose tolerance
Increased protein GLUT-4 expression
Creatine has shown benefits in:
Insulin resistance
Enhancements in insulin sensitivity
Improvements in glucose tolerance
Increased protein GLUT-4 expression
Obese, inactive, men and women with type 2 DM were assigned to 5g/d creatine mono (n=13) or placebo (n=12) for 12 weeks.
GFR was measured by Cr-EDTA clearance to remove the impact of natural degradation of Creatine to creatinine as a cofounder.
PCR content was measured by use of 31p-MRS.
A supervised aerobic and resistance training program was done by all 3d/w for 12 weeks.
PCR content was measured by use of 31p-MRS.
A supervised aerobic and resistance training program was done by all 3d/w for 12 weeks.
Important finding #1
PCR went up in the creatine group but GFR did not go down.
PCR went up in the creatine group but GFR did not go down.
Important finding #2
3 subjects in the placebo group and 2 in the creatine had microalbuminuria at baseline. One in the creatine group had macroalbuminuria at baseline.
All but 1 in placebo group had improvements .
So, creatine did not make it worse. (Small # subjects I know)
3 subjects in the placebo group and 2 in the creatine had microalbuminuria at baseline. One in the creatine group had macroalbuminuria at baseline.
All but 1 in placebo group had improvements .
So, creatine did not make it worse. (Small # subjects I know)
“In this context,we provide evidence that 3 months of CR supplementation may not affect kidney function in older individuals,even with CKD and insulin resistance,supporting the development of further studies focused on the therapeutic role of CR for this population.”
No kidneys were harmed in this study.
Read the full study here: https://link.springer.com/article/10.1007/s00421-010-1676-3
Kidneys and creatine. May be interesting to you @nephondemand?
