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Has anyone else found cannabis to be helpful for their #MCAS? I’ve been in a horrible flare today triggered by trying to clean a really dusty area of our apartment. None of the usual meds and supplements worked, so, I took an edible and am now 80% better.
I’ve been trying to figure out the possible mechanism (something more specific than “pot is anti-inflammatory”) and stumbled into PPAR-γ (Peroxisome proliferator-activated receptor gamma) which is a pretty interesting receptor.
CBD may induce activation of PPAR-γ in mast cells ( https://www.jimmunol.org/content/194/11/5211.short), which suppresses mast cell maturation and induces mast cell apoptosis ( https://pubmed.ncbi.nlm.nih.gov/28656266/ ). It also looks like PPAR-γ may inhibit tryptase release by mast cells ( https://www.pnas.org/content/99/23/15072).
As a bonus, CBD may have the property of stimulating the production of lysyl hydroxylase, a key enzyme in collagen biosynthesis. https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbmr.2513
Apparently, Larry Afrin speculates about this a bit in his book. However, it’s never come up with my doctor or in conversations with other #MCAS patients. I’d love to hear if anyone else has found CBD, THC, or both to be helpful for their MCAS.
Curious if any of this research/speculation has come across your radar, and in particular PPAR-γ @RuhoyMD @microbeminded2 @MBVanElzakker @DrEReinhold @farid__jalali @BendyBrain
Also, are there other PPAR-γ agonists? Cc: @maureviv
This is important. “CB1 receptors are, however, functional in these mast cells, since they can contribute to suppression of secretory responses.” https://twitter.com/josh_koch/status/1348452452773859330?s=20
