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Still learning and sharing from this great book. Now on to thread 6 
BASICS OF BLOODS: BONE PROFILE
BASICS OF BLOODS: BONE PROFILE
Preceding thread links if you missed them. Otherwise keep scrolling!
1: What are we measuring
https://twitter.com/palingclaire/status/1333101314339983362?s=21
2: Family groups https://twitter.com/palingclaire/status/1334519307485720578?s=21
3: Blood Count
https://twitter.com/palingclaire/status/1335624811851243520?s=21
4: Inflammation
https://twitter.com/palingclaire/status/1338151490087686150?s=21
5: Autoimmunity
https://twitter.com/palingclaire/status/1340564265523097600?s=21
1: What are we measuring
https://twitter.com/palingclaire/status/1333101314339983362?s=21
2: Family groups https://twitter.com/palingclaire/status/1334519307485720578?s=21
3: Blood Count
https://twitter.com/palingclaire/status/1335624811851243520?s=21
4: Inflammation
https://twitter.com/palingclaire/status/1338151490087686150?s=21
5: Autoimmunity
https://twitter.com/palingclaire/status/1340564265523097600?s=21
A typical blood profile might measure:
- Calcium
- Phosphate
- Albumin
- Alkaline phosphotase
And sometimes:
- Vitamin D
- Parathyroid hormone
To understand the results, it's useful to have some knowledge of normal bone turnover...
- Calcium
- Phosphate
- Albumin
- Alkaline phosphotase
And sometimes:
- Vitamin D
- Parathyroid hormone
To understand the results, it's useful to have some knowledge of normal bone turnover...
OsteoClasts break down bone, releasing calcium.
OsteoBlasts mineralise the bone (B for build).
Bone turnover is moderated by processes involving parathyroid hormone & vitamin D (which increase the rate of bone turnover) & oestrogen (which suppresses the rate of bone turnover).
OsteoBlasts mineralise the bone (B for build).
Bone turnover is moderated by processes involving parathyroid hormone & vitamin D (which increase the rate of bone turnover) & oestrogen (which suppresses the rate of bone turnover).
Dysfunctional regulation of osteoclast & osteoblast activity can lead to imperfect removal & reabsorbtion of calcium.
This can lead to conditions like Paget's disease.
The tests within the bone profile can give clues about bone turnover.
This can lead to conditions like Paget's disease.
The tests within the bone profile can give clues about bone turnover.
MAGNESIUM is required to produce parathyroid hormone which is involved in the bone turnover process.
Deficiency may therefore restrict availability of free calcium.
Magnesium is often low is alcoholism, Chron's and pancreatitis for example.
Deficiency may therefore restrict availability of free calcium.
Magnesium is often low is alcoholism, Chron's and pancreatitis for example.
ALKALINE PHOSPHOTASE is an enzyme.
It is found in the bone, liver & kidney so can be a helpful differential.
Eg, if alk phosphotase raised on liver function testing but all other liver tests are normal, it might suggest that the cause is bone, especially with raised calcium.
It is found in the bone, liver & kidney so can be a helpful differential.
Eg, if alk phosphotase raised on liver function testing but all other liver tests are normal, it might suggest that the cause is bone, especially with raised calcium.
PHOSPHATE forms a complex with CALCIUM to make the structure of bone.
Both calcium and phosphate are involved in muscle control. Low levels can lead to respiratory failure.
Both calcium and phosphate are involved in muscle control. Low levels can lead to respiratory failure.
As always, there's more detail in the book but I hope these threads are useful for getting our heads round the basics!
Thanks for scrolling! Kidney function next week - see you then! Hope lock down is treating you all ok in the meantime
Thanks for scrolling! Kidney function next week - see you then! Hope lock down is treating you all ok in the meantime
