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A 28-yo female presents with mild hyperglycemia since 12 yo. She is active with a BMI of 21 Kg/m². Her father has long-last diabetes without complications.
Final diagnosis: MODY - do not miss it! Follow the
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#MedEd #tweetorial #diabetes
Final diagnosis: MODY - do not miss it! Follow the
(1/3)
#MedEd #tweetorial #diabetes
MODY represents 2-5% of diabetes.
- Monogenic;
- Autosomal dominant;
- Many patients are misdiagnosed with type 1/2 diabetes.
WHEN TO SUSPECT?
- Clinical features do not fit for type 1/2 diabetes;
- Young, thin, no diabetes symptoms, positive familiar history.
(2/3)
- Monogenic;
- Autosomal dominant;
- Many patients are misdiagnosed with type 1/2 diabetes.
WHEN TO SUSPECT?
- Clinical features do not fit for type 1/2 diabetes;
- Young, thin, no diabetes symptoms, positive familiar history.
(2/3)
Most common causes:
- HNF1A/HNF4A mutation: defect in insulin secretion. Post-prandial hyperglycemia and glycosuria. TREATMENT: SULFONYLUREA!
- GCK mutation: higher threshold for insulin secretion. Mild hyperglycemia throughout the day. TREATMENT NOT NEEDED!
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- HNF1A/HNF4A mutation: defect in insulin secretion. Post-prandial hyperglycemia and glycosuria. TREATMENT: SULFONYLUREA!
- GCK mutation: higher threshold for insulin secretion. Mild hyperglycemia throughout the day. TREATMENT NOT NEEDED!
(3/3)
