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A thread on vaccines that induce a better and more efficient long-lasting immunity. It is a misunderstanding often brought up that natural infection induces a better immune response than a vaccine. There are at least four different vaccines that gives better immunity. /1
First example is the vaccine to Human papillomavirus. This vaccine is highly immunogenic and gives än efficient antibody response in 98% of individuals. This vaccine gives almost 100% prevention of HPV persistent infection and e.g. cervical intraepithelial neoplasia. /2
Secondly the Tetanus vaccine where the active component is the highly immunogenic tetanus toxin and this induces a better antibody response than during the natural infection. A recent paper https://pubmed.ncbi.nlm.nih.gov/32095828/ by @MarkSlifka and collaborators show that there /3
is no benefit associated with booster vaccination of Tetanus in adulthood if the full vaccination schedule was followed during childhood. Third, Haemophilus Influenzae type b vaccine which due to the conjugation of a protein carrier to the polysaccharide capsule /4
gives an efficient immune response in more than 95% of vaccinated infants. Fourth, pneumococcal vaccine that works in a similar way as the Haemophilus Influenzae type b vaccine. In summary, do not listen to those that claim that natural infection always gives a better immunity/5
Since the SARS-CoV-2 inhibits the germinal centre reaction it is possible that also this vaccine will induce a more long-lasting immunity than the natural infection, but we do not have the data for this yet. /6 fine
