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I’m excited to share that my first @BurdickLab review paper titled “Chemically Modified Biopolymers for the Formation of Biomedical Hydrogels” was published in Chemical Reviews @ACSChemRev over the holidays! #Hydrogels #Biomaterials @pennbioeng (1/n) https://pubs.acs.org/doi/10.1021/acs.chemrev.0c00923
In this review, we first discuss polysaccharides and polypeptides used for hydrogel formation as well as common conjugation mechanisms used to modify these biopolymers. (2/n)
The bulk of the review focuses on crosslinking mechanisms for hydrogel formation, including 1) covalent crosslinking (ex: free radical chain polymerization), 2) dynamic covalent crosslinking (ex: Schiff base), and 3) physical crosslinking (ex: guest–host). (3/n)
To conclude, we discuss examples of recent advances using chemically modified biopolymer hydrogels for biofabrication, therapeutic delivery, tissue adhesives and sealants, as well as the formation of interpenetrating network biopolymer hydrogels. (4/n)
Working with @BurdickLab on this review has been an amazing experience, and I am excited to share the work with you all! #Biopolymers #Polymers #Conjugation #ChemRev #SciTwitter #Chemistry #Biomedical
