Talk in the UK (& Germany & Denmark) of using just 1 #COVID19 #vaccine dose/person for now, possibly providing boosters months later, is distressing.
A quick thread follows.
1.) @Pfizer has been clear as a bell: 1 dose = 52% protection, 2 doses = 95%
MORE https://www.bmj.com/content/371/bmj.m4826
A quick thread follows.
1.) @Pfizer has been clear as a bell: 1 dose = 52% protection, 2 doses = 95%
MORE https://www.bmj.com/content/371/bmj.m4826
2/ Compare those 52% vs 95% numbers to #measles. After Dose 1 a child is 69% protected against measles, but that jumps to 91% w/2nd dose. Given measles is ultra-contagious (Ro up to 18!) anything <90% is awful.
MORE
https://www.sciencedirect.com/science/article/pii/S0264410X01002079 and
https://www.who.int/immunization/newsroom/multimedia/Chapter_1.pdf?ua=1#:~:text=1.4%20Epidemiologic%20features%20of%20measles&text=The%20basic%20reproduction%20number%2C%20Ro,infectious%20communicable%20disease%20%5B18%5D.
MORE
https://www.sciencedirect.com/science/article/pii/S0264410X01002079 and
https://www.who.int/immunization/newsroom/multimedia/Chapter_1.pdf?ua=1#:~:text=1.4%20Epidemiologic%20features%20of%20measles&text=The%20basic%20reproduction%20number%2C%20Ro,infectious%20communicable%20disease%20%5B18%5D.
3/ In contrast, #hepatitisB vaccine offers up to 93% protection w/1 dose & 97.8% w/2 doses. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852093/
The virus is not very contagious (Ro<1), and not airborne, so a single dose of vaccination may be adequate for people who aren't sexually active.
MORE
The virus is not very contagious (Ro<1), and not airborne, so a single dose of vaccination may be adequate for people who aren't sexually active.
MORE
4/ #COVID19 is clearly an airborne contagion, between measles I hepatitis B. So what is the "wisdom" of the UK plan to give only the first @pfizer vaccine jab, besides managing to get it into the arms of more Brits?
MORE https://www.wsj.com/articles/u-k-delays-second-covid-19-vaccine-dose-as-europe-ponders-how-to-speed-up-immunization-11609334172?campaign_id=9&emc=edit_nn_20201231&instance_id=25533&nl=the-morning®i_id=80724309&segment_id=48102&te=1&user_id=539834d832680a57fa7414bdd30c20e6
MORE https://www.wsj.com/articles/u-k-delays-second-covid-19-vaccine-dose-as-europe-ponders-how-to-speed-up-immunization-11609334172?campaign_id=9&emc=edit_nn_20201231&instance_id=25533&nl=the-morning®i_id=80724309&segment_id=48102&te=1&user_id=539834d832680a57fa7414bdd30c20e6
5/ @pfizer is unhappy w/UK because its study "was designed to eval safety & efficacy following a 2-dose schedule, separated by 21 dys. Safety & efficacy has not been eval'ed on different dosing scheds." Plus, no one knows response duration after 1 dose. https://www.fool.com/investing/2020/12/31/pfizer-criticizes-sudden-change-in-coronavirus-dos/
6/ And then there's the question of UNDER-immunization and potential selection of vaccine-escape mutants. I'll let you mull that one yourselves.
Hint: look at #pertussis aka whooping cough https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530967/
Hint: look at #pertussis aka whooping cough https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530967/