Back at work in 2021 and pleased to share our paper on subsets of T follicular helper cells which drive induction of functional antibodies in humans with malaria 1/ https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(20)30204-4#.X_JuOUC1jfY.twitter
Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium...

Chan et al. used experimental P. falciparum malaria infection in Australian adults to study Tfh cell activation and antibody induction. They provide evidence for an association between Th2-Tfh...

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(20)30204-4#.X_JuOUC1jfY.twitter
Previous studies have shown that during malaria in children, Th1-Tfh subsets are preferentially activated, but this activation isn't associated with antibody induction. https://doi.org/10.1016/j.celrep.2015.09.004

Are other Tfh subsets important in driving antibody development in malaria? 2/
Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated...

Malaria-specific antibody responses are short lived in children, leaving them susceptible to repeated bouts of febrile malaria. The cellular and molec…

https://doi.org/10.1016/j.celrep.2015.09.004
To investigate this, we studied Tfh cells and antibody development during experimental malaria infection in humans. While all Tfh subsets were activated, only Th2-Tfh cells were associated with functional antibody development. 3/
Functional antibodies are important in immunity to malaria. While many questions remain, this work takes a first step in identifying Tfh cell subsets that could be targeted by malaria vaccines to improve functional antibody induction and vaccine efficacy. 4/
Many thanks to all study participants, funders and collaborators for making this work possible. Also to the editorial desk at @CellRepMed for an easy submission and review process, and the reviewers who made this publication significantly better! end/
You can follow @DrMichelleBoyle.
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