Read on Twitter
The one dose, two dose, issue, for my followers. No answers from me - just pointers to cogent arguments on either side. 1/
A thread from a vaccinologist. He points out vaccine overall response almost always is higher if the two dose schedule is more spread out. We don't have precise data - but he would "eat his hat" if Pfizer or Moderna were different. Refs provided. 2/ https://twitter.com/sandyddouglas/status/1344949258483621888?s=20
The standard FDA response is we approve things based on our FDA process, and using doses not tested is simply something we do not do. 3/ https://twitter.com/JamesEKHildreth/status/1345092765273698306?s=20
And a practical answer is that we cannot get the doses we have into arms, what makes us think we could double our current efforts! 4/ https://twitter.com/EricTopol/status/1345121712396926976?s=20
So this makes the UK efforts to stretch the Pfizer/BioNTech vaccine risky. They are using unproven approaches that WILL LIKELY save many lives. In the US, we have a real vaccine rollout problem that needs addressing first. 5/5
