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Breaking:
Moderna's vaccine trial is live in the New England Journal of Medicine.
Frontline insta-analysis by @Brief_19's @macacharya and me is here: https://brief19.com/2020/12/30/moderna-vaccine-phase-iii-trial-results-released-in-new-england-journal-of-medicine
Topline findings in this thread including some interesting data on whether one dose is useful.
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Moderna's vaccine trial is live in the New England Journal of Medicine.
Frontline insta-analysis by @Brief_19's @macacharya and me is here: https://brief19.com/2020/12/30/moderna-vaccine-phase-iii-trial-results-released-in-new-england-journal-of-medicine
Topline findings in this thread including some interesting data on whether one dose is useful.
1/
Main findings:
94% effective against Covid-19 ILLNESS.
Infection or contagion not studied.
30 severe cases of COVID-19 occurred.
All placebo group.
One death among severe cases occurred.
https://cdf.nejm.org/services/GetOnlineFirstPDF.aspx?DOI=NEJMoa2035389
(we are still parsing thru this)...
94% effective against Covid-19 ILLNESS.
Infection or contagion not studied.
30 severe cases of COVID-19 occurred.
All placebo group.
One death among severe cases occurred.
https://cdf.nejm.org/services/GetOnlineFirstPDF.aspx?DOI=NEJMoa2035389
(we are still parsing thru this)...
Researchers looked at patients <65 years old and also those with prior infection. Similar outcomes. All good news.
Interestingly, they also looked at effect of vaccine 14 days after the first dose (see figure in previous tweet).
Let's be very careful here.
The news appears good and it appears to add to data similar story in FDA document on this.
https://www.fda.gov/media/144434/download
Let's be very careful here.
The news appears good and it appears to add to data similar story in FDA document on this.
https://www.fda.gov/media/144434/download
In the FDA filing, it was reported that at 28 days, one dose was 92% effective compared to placebo.
Careful though! While this implies one dose is "almost as good as two," we do NOT know whether this will be long-lasting.
Would be a disaster if that effect fades by 60-120 days
Careful though! While this implies one dose is "almost as good as two," we do NOT know whether this will be long-lasting.
Would be a disaster if that effect fades by 60-120 days
More analysis soon! @Brief_19 https://brief19.com/subscribe/
