Read on Twitter
It's been so exciting to see all the discussion about the @JAMANetworkOpen paper about #SARS-CoV-2 in pregnancy. maternal viral load, vert transmission, placenta infxn, and plac antibody passage... a tweetorial with my opinions re key findings (thread)! https://ja.ma/34SZjkd
Key take-home points:
1) Reduced transplacental Ab transfer of SARS-CoV-2 Abs, w preserved transfer of anti-flu (HA) Abs. Our new paper @CellCellPress ( https://www.cell.com/cell/fulltext/S0092-8674(20)31749-9 ) drills down on mechanism. 2) No maternal viremia 3) No vertical transmission 4) No placental infxn
1) Reduced transplacental Ab transfer of SARS-CoV-2 Abs, w preserved transfer of anti-flu (HA) Abs. Our new paper @CellCellPress ( https://www.cell.com/cell/fulltext/S0092-8674(20)31749-9 ) drills down on mechanism. 2) No maternal viremia 3) No vertical transmission 4) No placental infxn
We are not arguing that vert transmission or placental infection (or viremia) never happen; there are convincing case reports of vert transmission & placental infxn. Our results simply highlight these are rare. Future research should focus on protective mechanisms.
This was a prospective cohort study of pregnant people getting care at 3 tertiary care centers in Boston, Massachusetts, April-June 2020 (height of 1st wave in Boston). @MassGeneralNews @BrighamWomens @BIDMC_ObGyn. @ob_kjg @airisyc and @DrJLi were key collaborators.
Pregnant people with + SARS-CoV-2 nasopharyngeal (NP) RT-PCR were cases (N=64), and contemporaneous participants negative for SARS-CoV-2 (known from universal screening, N=63) were enrolled as convenience sample. We felt appropriate controls were essential part of study.
