Read on Twitter
A few thoughts on this study:
https://www.nmcd-journal.com/article/S0939-4753(20)30504-4/pdf
1) Small. n = 12 in both arms.
2) Randomized, all food provided: this is good.
3) Two diets both 500 kcal hypocaloric as compared to RMR testing, 40/30/30% vs 55/15/30% CHO/PRO/FAT.
1/ https://twitter.com/tednaiman/status/1341626117380210688
https://www.nmcd-journal.com/article/S0939-4753(20)30504-4/pdf
1) Small. n = 12 in both arms.
2) Randomized, all food provided: this is good.
3) Two diets both 500 kcal hypocaloric as compared to RMR testing, 40/30/30% vs 55/15/30% CHO/PRO/FAT.
1/ https://twitter.com/tednaiman/status/1341626117380210688
"Monounsaturated and polyunsaturated fats were the main fats types, i.e. nuts and plant oils, and dietary carbohydrates included mostly whole grains, fruits and vegetables. Sources of dietary protein included fish, lean meats, chicken, eggs and low fat dairy foods."
OGTTs and other labs obtained at 30 minute intervals––no CGM for the glucose portion.
Very interesting bit is that despite similar compliance (93% vs 94%) and _greater_ weight loss in the high carb group (11.3% vs 9.8%, n.s.) 12/12 remission of prediabetes in HP, 4/12 in HC.
Very interesting bit is that despite similar compliance (93% vs 94%) and _greater_ weight loss in the high carb group (11.3% vs 9.8%, n.s.) 12/12 remission of prediabetes in HP, 4/12 in HC.
Again, with slightly greater trend of weight loss in HC vs HP group, significant differences at 6 months with HP group better in: OGTT AUC, insulin AUC, HOMA-IR, beta cell function, HbA1C. (Both also significantly different than baseline, of course).
attn @kevinnbass
attn @kevinnbass
"Lean Mass (LM) percent was significantly increased in the HP diet group at 6 months; whereas, the HC diet group lost significant LM. Both diet groups lost significant Fat Mass (FM) after 6 months on the diets."
Lower oxidative stress in HP group at 6 mo as well:
"The HP diet subjects had a significant decrease in oxidative stress as measured by lipid peroxidase (malondialdehyde) and inflammation (IL-1B, TNF-α) at 6 months compared to the HC subjects." Also sig lower hsCRP.
"The HP diet subjects had a significant decrease in oxidative stress as measured by lipid peroxidase (malondialdehyde) and inflammation (IL-1B, TNF-α) at 6 months compared to the HC subjects." Also sig lower hsCRP.
Re energy trafficking, again showing that carbs --> FFAs.
"Free fatty acids levels were not significantly different at baseline but the HP group had significantly lower FFAs at 6 months while the HC group had significantly higher FFAs level at 6 months."
"Free fatty acids levels were not significantly different at baseline but the HP group had significantly lower FFAs at 6 months while the HC group had significantly higher FFAs level at 6 months."
Overall I'm quite impressed by these results. To me, they clearly show that the "calorie is a calorie" approach is not true. Similarly not true is that measures of glycemic control, etc. will strictly follow _weight loss_.
I clearly forgot to keep up my numbering system from post 1! Whoops.
/fin.
/fin.
