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(1) Update: The new variant has been labeled VUI-202012/01 and has:
•17 functional single-nucleotide variants (8 on the S-gene)
•6 variants and 2 deletions in the S-gene (which codes for the spike protein)
•6 “synonymous mutations” in ORF1ab and the M-gene (no big deal)
•17 functional single-nucleotide variants (8 on the S-gene)
•6 variants and 2 deletions in the S-gene (which codes for the spike protein)
•6 “synonymous mutations” in ORF1ab and the M-gene (no big deal)
(2)
•An Orf8 truncation that leaves the virus open to more mutations
•71% increase in contagiousness
•~2.5x increase in R-value (still very preliminary)
•4x higher average viral load
•exhibiting exponential growth even during full lockdown (bad!)
•An Orf8 truncation that leaves the virus open to more mutations
•71% increase in contagiousness
•~2.5x increase in R-value (still very preliminary)
•4x higher average viral load
•exhibiting exponential growth even during full lockdown (bad!)
(3/3)
•no increase in severity of illness (which is a good thing)
Source: https://dalewharrison.substack.com/p/new-uk-coronavirus-variant?fbclid=IwAR3LIV_Txin-gjfbCeowU2mfLQLWA8_Q0Z5jfEuGg5OUwrwwsQJd17aR-kY
•no increase in severity of illness (which is a good thing)
Source: https://dalewharrison.substack.com/p/new-uk-coronavirus-variant?fbclid=IwAR3LIV_Txin-gjfbCeowU2mfLQLWA8_Q0Z5jfEuGg5OUwrwwsQJd17aR-kY
Antibody-Dependent Enhancement
The simple definition of ADE is “raising antibodies that don’t protect, but actually make a viral infection even worse”.
Source: https://blogs.sciencemag.org/pipeline/archives/2020/12/18/antibody-dependent-enhancement
The simple definition of ADE is “raising antibodies that don’t protect, but actually make a viral infection even worse”.
Source: https://blogs.sciencemag.org/pipeline/archives/2020/12/18/antibody-dependent-enhancement
