Among Republicans who expressed hesitancy, the most common rationale was: "The risks of COVID-19 are being exaggerated". This, to me, is a clear demonstration of the corrosive effects of messaging by Trump and others.
Per the Times: "One reason [for the partisan gap] experts say, is the president...his repeated denigration of scientists and insistence that the pandemic is not a threat have contributed to a sense among his followers that the vaccine is either not safe or not worth taking"
But I also don't think it's a forgone conclusion - intentions may not translate to actual vaccination behavior. First, cues from officials and credible messengers will matter, as @matt_motta notes in the Times piece.
Second, we know from tons of scientific evidence that if a doctor recommends the vaccine that is a strong predictor of uptake.
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