If we move fast with trials for a single-dose vaccine, we might be able to double the number of people we can quickly vaccinate—ending this crisis sooner, helping with vaccine equity, and saving many lives. New piece from @michaelmina_lab and me. https://www.nytimes.com/2020/12/18/opinion/coronavirus-vaccine-doses.html

Here are some ways this could be put to trial quickly. Volunteers from low-risk, high-exposure groups within early phases, or people outside the EUA (who'd get a chance at earlier vaccination). https://twitter.com/SteveJoffe/status/1339923303981608960

Immunologists have also suggested half-dose/half-dose prime/booster trials. I know trials are expensive but there's a lot on the line—vaccinating the whole planet, much earlier. Just last April, we thought we'd need another 18 months for any vaccine, let alone ones this good.