Read on Twitter
The latest craze: ‘The vaccine hasn’t been shown to prevent transmission’.
There are MANY detailed threads on this, but there are some principles which make it nigh-on-impossible for this not to be the case (all just opinions, remember ;) ).
There are MANY detailed threads on this, but there are some principles which make it nigh-on-impossible for this not to be the case (all just opinions, remember ;) ).
Let's kick off with this:
1) Antibodies mop up *extracellular* virus.
2) CD8+ T cells lyse infected cells i.e. the source of *intracellular* virus.
They work together to target SARS-CoV-2 at different stages of its life cycle.
1) Antibodies mop up *extracellular* virus.
2) CD8+ T cells lyse infected cells i.e. the source of *intracellular* virus.
They work together to target SARS-CoV-2 at different stages of its life cycle.
If a SARS-CoV-2-infected individual coughs in the face of a vaccinated individual, the virus meets a different environment to an unchallenged person.
Many virions are spotted immediately by neutralising antibodies before they can find any ACE2. https://twitter.com/andrew_croxford/status/1334175141710934020?s=20
Many virions are spotted immediately by neutralising antibodies before they can find any ACE2. https://twitter.com/andrew_croxford/status/1334175141710934020?s=20
Many will, however, make it into the cells and begin replicating. This will happen also in vaccinated individuals. BUT... CD8 T cells, primed after vaccination (and likely more so after infection), recognise and lyse these cells, reducing amplification at this stage.
If the virus is successful and spills virions into the circulation, they again are immediately confronted with a person brimming with neutralising antibodies, thus inhibiting the feed-forward cycle and build up of ‘viral load’.
Rinse and repeat.
The cycle is broken.
Rinse and repeat.
The cycle is broken.
Viral load doesn’t just ‘appear’. It takes time to build up after infection, whether symptomatic or asymptomatic.
Viral load *IS LINKED* to transmission. I don’t think this statement is controversial. A recent paper, and one of many, on the topic. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243597
Viral load *IS LINKED* to transmission. I don’t think this statement is controversial. A recent paper, and one of many, on the topic. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243597
We know that the recent trials (Pfizer/Moderna) have shown that there is essentially no severe COVID in the vaccinated arms. We know that viral load is linked to severity, therefore, less viral load after vaccination, one way or another. https://www.nature.com/articles/s41467-020-19057-5
Viral load is also linked to testing positive. These incidence-over-time graphs we’ve been marvelling at show that there will be a reduced viral load, either by direct inhibition of infection, or subsequent inability to accumulate measurable viral load. https://twitter.com/EricTopol/status/1338918969642663937?s=20
If a trial wasn’t designed to answer the question that you want answered, doesn’t mean the answer isn’t staring you in the face from the data presented thus far.
It’s like not being able to see a forest because there are too many trees blocking your view.
It’s like not being able to see a forest because there are too many trees blocking your view.
My personal take: if we prevent the mechanisms by which viral load can accumulate, we reduce transmission. I don't see another option.
Same for measles.
Same for smallpox.
Same for (add vaccinable disease).
Same for measles.
Same for smallpox.
Same for (add vaccinable disease).
Get yours when you can. https://twitter.com/Daltmann10/status/1339144276014411777?s=20
Oh God here they come....
THIS IS NOT MEDICAL ADVICE.
PLEASE DO NOT GET YOUR MEDICAL ADVICE FROM TWITTER.
THIS IS JUST A BIT OF FUN.
G*ddammit.
THIS IS NOT MEDICAL ADVICE.
PLEASE DO NOT GET YOUR MEDICAL ADVICE FROM TWITTER.
THIS IS JUST A BIT OF FUN.
G*ddammit.
This must of course OBVIOUSLY be qualified by saying that there is NO substitute for a trial to address this question. I’m just extremely confident that it will turn out to be the case. https://twitter.com/andrew_croxford/status/1339156262001520640
I did another thread on a similar topic if you got this far and are still interested... https://twitter.com/andrew_croxford/status/1340600758945902598
