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Lots of questions about ivermectin for tx + prophylaxis. @srrezaie + I reviewed a bunch of articles
Bottom line: No high-quality evidence to support use for any indication in COVID19. Based on available data, this is another distraction like HCQ. Let's not fall for it again
Bottom line: No high-quality evidence to support use for any indication in COVID19. Based on available data, this is another distraction like HCQ. Let's not fall for it again
Ivermectin is an antiparasitic that's FDA approved for onchocerciasis, helminthiases, and scabies (most common use in US)
Limited side effects: rash, n/v diarrhea, neurologic (seizures)
Widely available in developing countries + dirt cheap
Limited side effects: rash, n/v diarrhea, neurologic (seizures)
Widely available in developing countries + dirt cheap
In vitro research ( http://bit.ly/3854a2N ) demonstrates that it inhibits SARS-CoV2 replication
but, bleach, alcohol + soap work in vitro too
but, bleach, alcohol + soap work in vitro too
Some pre-print RCTs ( http://bit.ly/2Kr6byb , http://bit.ly/3nAfo5C ) show benefit but major flaws including lack of blinding, multiple subjective endpoints, convenience samples, poor randomization
This data should not drive use
This data should not drive use
CHEST article http://bit.ly/3acu7QA has prompted many to consider use but this is a retrospective study, no randomization, unbalanced groups with lots of statistical manipulation
This is NOT evidence that it should be used. This IS evidence it should be researched
This is NOT evidence that it should be used. This IS evidence it should be researched
Until high-quality blinded RCTs are performed, ivermectin SHOULD NOT be used either for treatment or prophylaxis
NIH recs ( http://bit.ly/38bmoQb ) clear: "recommends against the use of ivermectin for the treatment of COVID-19, except in a clinical trial"
NIH recs ( http://bit.ly/38bmoQb ) clear: "recommends against the use of ivermectin for the treatment of COVID-19, except in a clinical trial"
