Read on Twitter
Today, I would like to talk about coffee, likely one of the most powerful geroprotective interventions out there, and some things I only recently learned about my own coffee consumption.
Epidemiologic studies shown that coffee consumption is associated with decreased rates of many diseases of aging, and some analyses suggest it is also associated with decreased all-cause mortality. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2686145?utm_source=TrendMD&utm_medium=cpc&utm_campaign=_JAMA_Internal_Medicine_TrendMD_1&origin=797cea8c7d6816c2d7fbf1f2b8c0a29d
Not all studies show this, and recent articles suggest there may be a difference in the effect of filtered vs. unfiltered (e.g. french press, expresso) coffee https://journals.sagepub.com/doi/10.1177/2047487320914443
In particular, unfiltered coffee is "associated with higher mortality than filtered brew" and didn't seem to have an overall benefit. Why might this be?
Well, it was shown back in 1991 in a randomized clinical trial that cholesterol-raising factors from boiled coffee does not pass a paper filter. https://pubmed.ncbi.nlm.nih.gov/2029499/
Conceptually, it makes sense that raising lipids might counteract some of the other beneficial effects of coffee. I have found a pour-over cone with a paper filter is a cheap and easy addition to my daily coffee routine! https://www.amazon.com/RSVP-Manual-Coffee-Carafes-Thermos/dp/B000BUDDTY/
Interestingly coffee (as well as caffeine itself) inhibit my favorite signaling pathway, #mTOR, and induces autophagy https://pubmed.ncbi.nlm.nih.gov/28526373/ https://pubmed.ncbi.nlm.nih.gov/24769862/
