A short #GIpath #tweetorial

A concerning finding on a colon resection...

@ariella8 @nucleololailo @DrGeeONE @kis_lorand @MAHoureih @D4L14H @DraEosina @SingJamieD @Pathmath1 @ALBoothMD @jansen_marnix @steland011 @Mvgs1706 @RunjanChetty @drtimbracey @AllonKahn
A short #GIpath #tweetorialA concerning finding on a colon resection... @ariella8 @nucleololailo @DrGeeONE @kis_lorand @MAHoureih @D4L14H @DraEosina @SingJamieD @Pathmath1 @ALBoothMD @jansen_marnix @steland011 @Mvgs1706 @RunjanChetty @drtimbracey @AllonKahn
A short #GIpath #tweetorialA concerning finding on a colon resection... @ariella8 @nucleololailo @DrGeeONE @kis_lorand @MAHoureih @D4L14H @DraEosina @SingJamieD @Pathmath1 @ALBoothMD @jansen_marnix @steland011 @Mvgs1706 @RunjanChetty @drtimbracey @AllonKahn
A short #GIpath #tweetorialA concerning finding on a colon resection... @ariella8 @nucleololailo @DrGeeONE @kis_lorand @MAHoureih @D4L14H @DraEosina @SingJamieD @Pathmath1 @ALBoothMD @jansen_marnix @steland011 @Mvgs1706 @RunjanChetty @drtimbracey @AllonKahn
@jake_bledsoe @natzpat @Dr_Brian_Cox @TristanRutland7 @CArnold_GI @slusagar @RZitwer

Some of these cells are showing classic ‘signet ring’ morphology:
@jake_bledsoe @natzpat @Dr_Brian_Cox @TristanRutland7 @CArnold_GI @slusagar @RZitwer Some of these cells are showing classic ‘signet ring’ morphology:
@jake_bledsoe @natzpat @Dr_Brian_Cox @TristanRutland7 @CArnold_GI @slusagar @RZitwer Some of these cells are showing classic ‘signet ring’ morphology:
Before we sign it out as “invasive signet ring carcinoma”, let’s take a look at lower power:
Before we sign it out as “invasive signet ring carcinoma”, let’s take a look at lower power:
Before we sign it out as “invasive signet ring carcinoma”, let’s take a look at lower power:
Before we sign it out as “invasive signet ring carcinoma”, let’s take a look at lower power:
How do we differentiate benign signet ring cell change from signet ring adenocarcinoma?

Context is key: signet ring cell change may be seen in pseudomembranous colitis; also other ischemic and ulcerative conditions.
The cause of signet ring cell change isn’t completely understood. Apparently, mucosal inflammation and ischemia cause epithelial cells to slough and ‘round up’, resulting in signet ring-like morphology.

For more detail see https://pubmed.ncbi.nlm.nih.gov/11257633/ 
The cause of signet ring cell change isn’t completely understood. Apparently, mucosal inflammation and ischemia cause epithelial cells to slough and ‘round up’, resulting in signet ring-like morphology.For more detail see https://pubmed.ncbi.nlm.nih.gov/11257633/ 
The cause of signet ring cell change isn’t completely understood. Apparently, mucosal inflammation and ischemia cause epithelial cells to slough and ‘round up’, resulting in signet ring-like morphology.For more detail see https://pubmed.ncbi.nlm.nih.gov/11257633/ 
Contrast the nuclear features of signet ring cell change with those of adenocarcinoma.
Contrast the nuclear features of signet ring cell change with those of adenocarcinoma.
Contrast the nuclear features of signet ring cell change with those of adenocarcinoma.
Contrast the nuclear features of signet ring cell change with those of adenocarcinoma.
Contrast the nuclear features of signet ring cell change with those of adenocarcinoma.
A helpful table from Dhingra and Wang “Nonneoplastic signet-ring cell change in gastrointestinal and biliary tracts: a pitfall for overdiagnosis”.

https://pubmed.ncbi.nlm.nih.gov/22082777/ 

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