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Hello, I am Shivani, an undergraduate student from India and I am excited to be a part of #GlobalScienceShow.
I will be talking about Sleep ain’t no snore
Next up is @ArvindBehal
#scicomm #AcademicChatter #STEM #sciencetwitter @VoicesofIndAcad
I will be talking about Sleep ain’t no snore
Next up is @ArvindBehal
#scicomm #AcademicChatter #STEM #sciencetwitter @VoicesofIndAcad
Sleep is an important part of our daily routine, but in this global pandemic, most of our sleep schedule has gone for a toss.
But have you ever wondered why do we feel sleepy? what happens when we sleep? or what happens if you don't sleep for one night?
You’re about to find out
But have you ever wondered why do we feel sleepy? what happens when we sleep? or what happens if you don't sleep for one night?
You’re about to find out
Sleep is regulated by Circadian rthymn, it’s just like a clock present inside our body but it's complicated because it is synchronized by eating patterns, light
& temperature
.
The central circadian pacemaker is in the suprachiasmatic nucleus (It is present in the brain
)
& temperature. The central circadian pacemaker is in the suprachiasmatic nucleus (It is present in the brain
)
Along with SCN, cells of the Blood
-Brain barrier (It is a functional separation between circulating blood and central Nervous system), have circadian rthymn driven by molecular clocks.
anything entering the brain needs to cross the Blood-Brain Barrier (BBB).
-Brain barrier (It is a functional separation between circulating blood and central Nervous system), have circadian rthymn driven by molecular clocks.anything entering the brain needs to cross the Blood-Brain Barrier (BBB).
The Blood-brain Barrier (BBB) permeability is controlled by sleep
and circadian rthymn.
When we sleep Endocytosis across the Blood-Brain Barrier is increased.
Now what is Endocytosis you ask
Endocytosis is a process by which cells take up molecules inside the cell.
and circadian rthymn.When we sleep
Endocytosis across the Blood-Brain Barrier is increased.Now what is Endocytosis you ask
Endocytosis is a process by which cells take up molecules inside the cell.
Too much to take in, let me simplify it or you.
Now just imagine you are hungry and have ordered food from Zomato
but to eat the food you need to open the door
, take in the food inside then eat
Just like that, cells take up molecules by endocytosis.
Now just imagine you are hungry and have ordered food from Zomato
but to eat the food you need to open the door
, take in the food inside then eatJust like that, cells take up molecules by endocytosis.
The molecules taken up by Blood-Brain Barrier via endocytosis are leptin, TNF-α, cytokines to name a few.
When endocytosis doesn’t occur, we feel sleepy.
So, the next time you feel sleepy it’s because endocytosis is inhibited.
When endocytosis doesn’t occur, we feel sleepy.
So, the next time you feel sleepy
it’s because endocytosis is inhibited.
It was also found that endocytosis occurs highest early during the night
and lowest early in the morning
.
Sleep also promotes the clearance
of metabolites out of the brain.
and lowest early in the morning.Sleep
also promotes the clearance of metabolites out of the brain.
During sleep, the interstitial spaces of the brain are larger, allowing for a more robust movement of metabolites.
Accumulation of β-amyloid in the brain aggregates to form plaques that lead to Alzheimer’s disease.
are larger, allowing for a more robust movement of metabolites. Accumulation of β-amyloid in the brain aggregates to form plaques that lead to Alzheimer’s disease.
β-amyloid was found to accumulate in interstitial fluid during wakefulness
and after sleep deprivation
, even if it’s just 1 night of sleep deprivation.
β-amyloid is cleared through multiple routes.
An age-related
decline is observed in the clearance of β-amyloid.
and after sleep deprivation, even if it’s just 1 night of sleep deprivation. β-amyloid is cleared through multiple routes.
An age-related
decline is observed in the clearance of β-amyloid.
What happens if you don’t sleep for some days
When sleep is restricted for 10 days, Blood-Brain Barrier Permeability increases, which means any molecule can now enter the brain.
Let me simplify it for you.
for some daysWhen sleep is restricted for 10 days, Blood-Brain Barrier Permeability increases, which means any molecule can now enter the brain.
Let me simplify it for you.
Consider the permeability of BBB as the watchman
that guards your house
, if the guard is gone anyone can enter.
Increased permeability attributes to inflammatory signalling which leads to the production of fewer junction proteins that hold the BBB together.
that guards your house, if the guard is gone anyone can enter.Increased permeability attributes to inflammatory signalling which leads to the production of fewer junction proteins that hold the BBB together.
When we take a nap, does everything go back to normal
Yes, when you take naps ranging between 40-120 mins the permeability is normalized.
To conclude, sleepis a highly regulated process and take your beauty sleep
, does everything go back to normalYes, when you take naps ranging between 40-120 mins the permeability is normalized.
To conclude, sleep
is a highly regulated process and take your beauty sleep
If you read till here, Thank you!
To read more about this https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(19)30060-8
https://pubmed.ncbi.nlm.nih.gov/23713739/
https://elifesciences.org/articles/43326
Fin
To read more about this https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(19)30060-8
https://pubmed.ncbi.nlm.nih.gov/23713739/
https://elifesciences.org/articles/43326
Fin
