1/4 Do fasting triglycerides shift anything to anything? They are undoubtedly a marker that your liver has more carbohydrate derived lipid than it requires, mostly from fructose. It is perfectly possible to understand how fructose in the portal vein

2/4 or Hyperglycemia in the systemic circulation might modify the apoB100 to reduce the residual moiety's ability to be endocytosed. But that's glucotoxicity, not lipotoxicity. Equally you might have alterations in the lipid composition in VLDLs specifically caused by

3/4 fructose detoxification to palmitic acid. Those changes give a lipid pattern which is a clear flag for fructose intake. So you have to ask whether that alteration in the fasting triglycerides is toxic per se, i.e your liver is out to kill you,

4/4 or if it was the fructose you chose to eat which is killing you and fasting trigs are merely the messenger telling you that there is an assassin on your plate.

Thanks to Petro Dobromylskyj