one of the striking features of covid has been how much it has been a disease predominantly affecting the very old.

unlike flu, a notorious killer of children, it has left kids all but alone.

there have been 17 deaths in the whole US from ages 1-4, 1/8 that of flu/pneumonia
there is a new article in nature seeking to explain this.

they conclude that it is the untrained nature of children's immune systems that make their response so effective.

this is precisely what certain internet felines have been saying for months. https://www.nature.com/articles/d41586-020-03496-7?utm_source=twt_nnc&utm_medium=social&utm_campaign=naturenews
this was a key finding back in july:

the best t-cell mediated responses to covid 19 were not effective because they were intense, but rather because they were broadly activated.

you attacked it from several vectors. (recognition of multiple epitopes) https://twitter.com/boriquagato/status/1285558917033086982?s=20
this is good news from a "durable resistance" standpoint" as it's much harder for a virus to mutate away from multiple lines of defense all at once.

and it also explains why children have done so well: their immune systems attack everything.

they are not trained or calibrated.
from this, a strong picture starts to emerge:

covid is not a hard virus to kill if you have a well functioning immune system. it killed fewer americans under 55 than flu and pneumonia.

it disproportionately affects the old and unhealthy whose immune response is not robust.
this was never some wild zoonotic virus so novel that no one had resistance or ability to fight it.

it was a virus a healthy immune system readily recognized and generally was able to mount a rapid, effective defense against. https://twitter.com/boriquagato/status/1285558913845399552?s=20
for such people, this was not even flu level risk

this would seem to be a highly relevant fact when assessing schools & workplaces & the idea of societal lockdown

we broke all the systems that generate low risk community resistance & did so at staggering social & economic cost
2020 has been the year of the massive, needless policy own goal.

this has probably been the most expensive peace time policy in global history and it has bought nothing because it never made sense.

doubling down on these mistakes will be even more ruinous.
rats. i made an XLS error on that table.

it was locked to a cell in a prev version, so the %'s are wrong.

this is the corrected version.

apologies.
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