Read on Twitter
Super cool study:
Effects of CBD and THC on Driving Performance
Clinical trials involving simulated or real-world driving tests are done to assess for functional impairment. These trials are also commonly done for insomnia medications. https://jamanetwork.com/journals/jama/fullarticle/2773562
Effects of CBD and THC on Driving Performance
Clinical trials involving simulated or real-world driving tests are done to assess for functional impairment. These trials are also commonly done for insomnia medications. https://jamanetwork.com/journals/jama/fullarticle/2773562
The primary endpoint of these trials is change in the standard deviation of lateral position (SDLP). SDLP represents the amount of car "weaving" relative to driving in the center of the lane. More weaving (or a greater SDLP) indicates more impairment.
To put into clinical context, a change in SDLP of 2.4 cm has historically been used as a reference point. This represents the amount of impairment of someone driving with a blood alcohol concentration of 0.05%. Plots above threshold = clinically meaningful impairment (bad).
Here we see subjects that vaporized THC (13.75 mg) or THC-CBD (13.75 mg/13.75 mg) showed significantly greater impairment vs. PBO at 40 minutes. Interestingly, subjects that vaporized CBD (13.75 mg) alone did not show a difference vs. PBO.
Will admit I'm not familiar with THC/CBD dosing. Asking help from #MedTwitter and #RxTwitter: Is a dose of 13.75 mg (each of THC and CBD) considered low, moderate or high? #MedicalCannabis #CannabisMedicinal
