Thread by @JakeJordan8, Did someone say “start a thread on amygdala/fear memory lateralization”?!https://twitter.com/rodrigotrianad2/status/1336058018400628737 There’s a [...]

Did someone say “start a thread on amygdala/fear memory lateralization”?! https://twitter.com/rodrigotrianad2/status/1336058018400628737

https://twitter.com/rodrigotrianad2/status/1336058018400628737

There’s a few papers by Coleman-Mesches & McGaugh. Check this one on reward memory and find the two papers in refs (same authors) from ‘95 on inhibitory avoidance: https://www.sciencedirect.com/science/article/abs/pii/0166432895002316

Unilateral amygdala inactivation after training attenuates memory for reduced reward

This experiment examined the effects of unilateral inactivation of the amygdalae on memory for reduction in reward magnitude. Male Sprague-Dawley rats…

https://www.sciencedirect.com/science/article/abs/pii/0166432895002316

Then, there are a few papers on contextual (not tone!) retrieval being right lateralized. Check this paper from @StephenMaren : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311374/

Contextual and Auditory Fear Conditioning are Mediated by the Lateral, Basal, and Central Amygdal...

A large body of literature implicates the amygdala in Pavlovian fear conditioning. In this study, we examined the contribution of individual amygdaloid nuclei to contextual and auditory fear condit...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311374/

And this one from @Jeansok_Kim : https://pubmed.ncbi.nlm.nih.gov/14979779/

Amygdalar lateralization in fear conditioning: evidence for greater involvement of the right...

The relative contribution of left and right amygdalae in the acquisition and retention of fear conditioning was investigated in rats. Pretraining bilateral electrolytic lesions blocked the acquisit...

https://pubmed.ncbi.nlm.nih.gov/14979779/

And this one on right lateralized c-Fos expression: https://pubmed.ncbi.nlm.nih.gov/14979778/

Contextual fear conditioning is associated with lateralized expression of the immediate early gene...

Fos, the protein product of the immediate early gene c-fos, was used to map functional circuitry underlying contextual conditioned fear. Male rats were given footshocks in a distinctive context and...

https://pubmed.ncbi.nlm.nih.gov/14979778/

And in the anterior ACC, right hemisphere lesions impair observational fear conditioning: https://www.pnas.org/content/109/38/15497

Lateralization of observational fear learning at the cortical but not thalamic level in mice

Major cognitive and emotional faculties are dominantly lateralized in the human cerebral cortex. The mechanism of this lateralization has remained elusive owing to the inaccessibility of human brains...

https://www.pnas.org/content/109/38/15497

Only paper (that I’m aware of) that has done ventral hippocampal lateralization found greater involvement of right hemisphere in response to aversive environment: https://pubmed.ncbi.nlm.nih.gov/28235588/

Left-right functional asymmetry of ventral hippocampus depends on aversiveness of situations -...

Many studies suggest that animals exhibit lateralized behaviors during aversive situations, and almost all animals exhibit right hemisphere-dominant behaviors associated with fear or anxiety....

https://pubmed.ncbi.nlm.nih.gov/28235588/

And recently, male-specific increase in right amygdala plasticity following early life stress: https://www.jneurosci.org/content/40/43/8276.abstract

It Is All in the Right Amygdala: Increased Synaptic Plasticity and Perineuronal Nets in Male, But...

Early-life stress (ELS) is associated with increased vulnerability to mental disorders. The basolateral amygdala (BLA) plays a critical role in fear conditioning and is extremely sensitive to ELS....

https://www.jneurosci.org/content/40/43/8276.abstract

So, does the left amygdala have any specialized function?

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