To conclude "New Approaches to Cooling", Sudhin Thayyil ( @SudhinThayyil) of @imperialcollege discusses the “Hypothermia for Encephalopathy in Low and Middle-Income Countries (HELIX) Trial”

Trial protocol: https://pubmed.ncbi.nlm.nih.gov/28923118/ 

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Thayyil: current guidelines recommend therapeutic cooling in LMIC settings. Supported by MA findings, but based on small, low quality studies.

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Thayyil: current guidelines recommend therapeutic cooling in LMIC settings. Supported by MA findings, but based on small, low quality studies. #HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil: current guidelines recommend therapeutic cooling in LMIC settings. Supported by MA findings, but based on small, low quality studies. #HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil: Aim, setting, eligibility, sample size and target outcomes for the HELIX trial.

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Thayyil: Aim, setting, eligibility, sample size and target outcomes for the HELIX trial. #HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil: Aim, setting, eligibility, sample size and target outcomes for the HELIX trial. #HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil: Aim, setting, eligibility, sample size and target outcomes for the HELIX trial. #HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil: Aim, setting, eligibility, sample size and target outcomes for the HELIX trial. #HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil: Helix CONSORT diagram showing high enrollment rates and excellent follow up among 408 randomized infants.

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Thayyil: trial data suggest that therapeutic cooling was effectively applied, with clear differentiation in core temperatures between groups.

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Thayyil: primary outcomes of HELIX trial with remarkable results - more death in infants exposed to therapeutic cooling. Less severe disability among survivors.

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Thayyil: primary outcomes of HELIX trial with remarkable results - more death in infants exposed to therapeutic cooling. Less severe disability among survivors. #HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil: primary outcomes of HELIX trial with remarkable results - more death in infants exposed to therapeutic cooling. Less severe disability among survivors. #HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil: why unexpected finding of more death in infants exposed to therapeutic cooling? Could difference reflect differences in study population? One key difference was higher incidence of seizure in HELIX pop.

#HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil: why unexpected finding of more death in infants exposed to therapeutic cooling? Could difference reflect differences in study population? One key difference was higher incidence of seizure in HELIX pop. #HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil: why unexpected finding of more death in infants exposed to therapeutic cooling? Could difference reflect differences in study population? One key difference was higher incidence of seizure in HELIX pop. #HotTopicsNeo2020 @HotTopicsNeo #neoebm
Thayyil with concluding remarks on HELIX trial.

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