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1/4 The microbiota-gut-brain axis has a bidirectional communication through the autonomic nervous system. The vagus nerve -the principal component of the parasympathetic nervous system- is a mixed nerve composed of 80% afferent and 20% efferent fibers
https://www.frontiersin.org/article/10.3389/fnins.2018.00049
https://www.frontiersin.org/article/10.3389/fnins.2018.00049
2/4 The Vagus Nerve, because of its role in interoceptive awareness, is able to sense the microbiota metabolites, to transfer this gut information to the central nervous system, and then to generate an adapted or inappropriate response. inflammation.
inflammation.
3/4 A cholinergic anti-inflammatory pathway has been described through Vagus Nerve fibers, which is able to dampen peripheral inflammation and to decrease intestinal permeability, thus very probably modulating microbiota composition.
4/4 Stress inhibits the Vagus Nerve activity and has deleterious effects on the gastrointestinal tract and on the microbiota, and is involved in the pathophysiology of gastrointestinal disorders such as irritable bowel syndrome and inflammatory bowel disease.
