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#COVID19vaccines - #IndiaFightsCorona
News/Updates - India
Different Vaccines, Different Mechanisms
Time-frame and Roll-out
What To Expect?
Got Vaccinated. What now?
Adverse Reactions???
Countering Misinformation
A thread.
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News/Updates - IndiaDifferent Vaccines, Different MechanismsTime-frame and Roll-outWhat To Expect?Got Vaccinated. What now?Adverse Reactions???Countering MisinformationA thread.
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News/Updates - #India> @pfizer has applied for Emergency Approval in India.
> @BharatBiotech COVAXIN - Phase 3 trials.
> @ZydusUniverse ZyCoV-D - Expected to start Phase 3 trials in Dec/Jan
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Different Vaccines, Different MechanismsHere's a look at how the major vaccines work -
> Pfizer and Moderna - mRNA
> Oxford/AstraZeneca - Chimpanzee Adenoviral vector
> Bharat Biotech - Inactivated Vaccine
> Zydus Cadila - Plasmid DNA
https://www.nature.com/articles/d41586-020-01221-y
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This is a small article from @ReutersGraphics that explains the basic mechanisms of the vaccines under development with the help of graphics. Very easy to understand animations.
https://graphics.reuters.com/HEALTH-CORONAVIRUS/VACCINE/yzdpxqxnwvx/index.html
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https://graphics.reuters.com/HEALTH-CORONAVIRUS/VACCINE/yzdpxqxnwvx/index.html
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This link from the @CDCgov explains how our immunity works and how the different vaccines work.
It has been explained in a very simple and easy to understand manner.
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/how-they-work.html?CDC_AA_refVal=https://www.cdc.gov/coronavirus/2019-ncov/vaccines/about-vaccines/how-they-work.html
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It has been explained in a very simple and easy to understand manner.
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/how-they-work.html?CDC_AA_refVal=https://www.cdc.gov/coronavirus/2019-ncov/vaccines/about-vaccines/how-they-work.html
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Time-Frame and Roll-OutThe image below shows the normal process of Vaccine Development.
Most of the vaccines for COVID-19 are currently at Steps 3/4 - i.e. undergoing clinical trials or seeking approval.
Usually, it takes a few years to develop a vaccine.
But.....
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Welcome Operation Warp Speed - a mission launched by the USA to accelerate the vaccine development process.
The same approach has also been followed by other nations developing a vaccine.
More about #OperationWarpSpeed here: https://bit.ly/3mNsxbt via @DeptofDefense
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The same approach has also been followed by other nations developing a vaccine.
More about #OperationWarpSpeed here: https://bit.ly/3mNsxbt via @DeptofDefense
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What does this mean?
From Approval to Roll-out - it usually takes around 1-2 years for mass production and distribution.
With the accelerated development, this process has been shortened to 3-6 months for faster dissemination of the vaccines.
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From Approval to Roll-out - it usually takes around 1-2 years for mass production and distribution.
With the accelerated development, this process has been shortened to 3-6 months for faster dissemination of the vaccines.
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PM @narendramodi said that COVID vaccines may be ready in the next few weeks.
While that is good news, effectively, it'll still take 2-3 months before Vaccine Administration can begin as vaccine manufacture and supply chain logistics are worked out.
https://bit.ly/2JTt2SI
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While that is good news, effectively, it'll still take 2-3 months before Vaccine Administration can begin as vaccine manufacture and supply chain logistics are worked out.
https://bit.ly/2JTt2SI
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What To Expect?Once vaccines are approved and the vaccination drive begins - what should you expect?
> Who will get the vaccine first?
> How will vaccine administration work?
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> Who will get the vaccine first?
As per the PM's address -
> Frontline warriors - Healthcare Workers, Law Enforcement Personnel
> High Risk and Elderly People with co-morbidities
> Then - Long term vaccination drives to immunize everyone else.
https://bit.ly/2JTt2SI
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As per the PM's address -
> Frontline warriors - Healthcare Workers, Law Enforcement Personnel
> High Risk and Elderly People with co-morbidities
> Then - Long term vaccination drives to immunize everyone else.
https://bit.ly/2JTt2SI
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> How will vaccine administration work?
Most of the vaccines have a 2-dose regimen, 3-4 weeks apart.
Day 0 - First dose
Day 28 - Second dose
Both doses are necessary for complete immunization. A single dose will not impart protection against COVID-19.
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Most of the vaccines have a 2-dose regimen, 3-4 weeks apart.
Day 0 - First dose
Day 28 - Second dose
Both doses are necessary for complete immunization. A single dose will not impart protection against COVID-19.
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Got Vaccinated. What now?>FOLLOW MASKING AND SOCIAL DISTANCING.
Why?
>Vaccination doesn't mean immediate protection - it takes 2-3 weeks after the 2nd dose for immunity to develop.
>From Day 0 to Day 60 - you can still get infected - hence precautions are a must.
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Vaccination will give you personal protection. But it doesn't mean the virus has stopped causing infections in others.
Until a majority of the population gets vaccinated, the basic precautionary measures must be followed - irrespective of whether you got vaccinated or not.
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Until a majority of the population gets vaccinated, the basic precautionary measures must be followed - irrespective of whether you got vaccinated or not.
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Adverse Reactions???>It is common for vaccines to cause minor side effects like-
*Fever
*Headache
*Rash at the injection site
*Weakness/Fatigue
It is not a cause for concern - these side effects usually resolve in a few days.
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As of yet, none of the vaccine manufacturers have published a complete Vaccine Information Sheet with dosing info and safety profile - it is expected that more info will follow as vaccines are granted regulatory approval and the Phase 3 clinical trial results are published.
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Countering Misinformation>Vaccines WILL NOT cause COVID infection - none of the vaccine candidates contain the live virus capable of causing an infection.
>The vaccines will not alter your DNA - the vaccines don't interact with your DNA or cause any changes to it.
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>Conspiracy theorists/anti-vaxxers may attempt to spread misinformation - trust info only from official/verified sources.
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FAQs about COVID vaccination from @CDCgov
https://www.cdc.gov/coronavirus/2019-ncov/vaccines/faq.html
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https://www.cdc.gov/coronavirus/2019-ncov/vaccines/faq.html
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A comprehensive list of myths and facts about COVID-19 from the @WHO.
https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public/myth-busters
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https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public/myth-busters
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To sum up:
>Vaccines are in the final phases of development and might be available in 2-3 months.
>Vaccines are safe - with few expected minor side effects.
>Vaccines will protect you from COVID infection - but only after a window period of 2-3 weeks after the 2nd dose.
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>Vaccines are in the final phases of development and might be available in 2-3 months.
>Vaccines are safe - with few expected minor side effects.
>Vaccines will protect you from COVID infection - but only after a window period of 2-3 weeks after the 2nd dose.
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