Looking forward to moderating oral presentations on biomarkers and prognostication in aggressive #lymphoma with @SoniSmithMD on Monday morning. We have some exciting #ASH20 abstracts to discuss. https://ash.confex.com/ash/2020/webprogram/Session19579.html #lymsm 1/7
. @lymphomatic et al. NGS-MRD CSF assay detects CNS involvement in DLBCL not detected by conventional CSF methods. Small numbers in this proof of concept study but intriguing 100% sensitivity for CNS relapse. #lymsm #lymphoma #ASH20
https://ash.confex.com/ash/2020/webprogram/Paper134757.html 2/7
Merryman et al ctDNA using IgNGS at time of apheresis is a strong predictor of relapse after ASCT. Potential for predictive biomarker to conventional ASCT approach in r/r DLBCL setting #LRFCRMP #ASH20 #lymsm #lymphoma @lymphoma
https://ash.confex.com/ash/2020/webprogram/Paper140965.html
3/7
Herrera et al Baseline ctDNA have independent prognostic value for outcomes for R/R DLBCL treated with BR +/- POLA. Potential for predictive biomarker to approved regimen in the space, aid with therapy selection. #lymsm #lymphoma #ASH20
https://ash.confex.com/ash/2020/webprogram/Paper136645.html 4/7
Song et al. Presence of TP53 inactivation *and* double-hit signature defines poor outcome group in de novo GCB DLBCL. Tumors negative for one or both features had good to intermediate outcomes. #ASH20 #lymsm #lymphoma
https://ash.confex.com/ash/2020/webprogram/Paper137258.html 5/7
Boddicker et al. Clonal somatic mutations present in peripheral blood of 6.5% of newly diagnosed DLBCL (most > age 60 years). CHIP associated with inferior EFS on immunochemotherapy; independent of age, sex, and IPI. #lymsm #ASH20 #lymphoma

https://ash.confex.com/ash/2020/webprogram/Paper141726.html

6/7
Eertink et al. Radiomic features significantly improve identification of high risk patients beyond clinical variables in newly diagnosed DLBCL. Elucidates the potential prognostic yield of radiomics & std clinical data. #lymsm #lymphoma #ASH20
https://ash.confex.com/ash/2020/webprogram/Paper140245.html
7/7
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