1/ #PathTwitter what is your understating on this skeletal metastasis in an elderly female? ![Denkendes Gesicht 🤔](https://abs.twimg.com/emoji/v2/72x72/1f914.png)
#pathology
@smlungpathguy @natasharekhtman
![Denkendes Gesicht 🤔](https://abs.twimg.com/emoji/v2/72x72/1f914.png)
#pathology
@smlungpathguy @natasharekhtman
![Rückhand Zeigefinger nach unten 👇](https://abs.twimg.com/emoji/v2/72x72/1f447.png)
2/ #CUP
3/ #IHCpath
7/ So indeed this was a metastatic breast carcinoma and the answer and the problem lies in the non-specificity of the SP24 antibody as highlighted buy several of you ![Thumbs up 👍](https://abs.twimg.com/emoji/v2/72x72/1f44d.png)
more specifically metastatic lobular carcinoma
![Thumbs up 👍](https://abs.twimg.com/emoji/v2/72x72/1f44d.png)
more specifically metastatic lobular carcinoma
![Grinsendes Gesicht mit lächelnden Augen 😁](https://abs.twimg.com/emoji/v2/72x72/1f601.png)
8/ Fun fact
Did you know that the well-known prostate-specific IHC marker NKX3.1 is positive in 25-28% av lobular breast carcinomas also? Say what
![Lächelndes Gesicht mit geöffnetem Mund und lächelnden Augen 😄](https://abs.twimg.com/emoji/v2/72x72/1f604.png)
![Gesicht mit Freudentränen 😂](https://abs.twimg.com/emoji/v2/72x72/1f602.png)
9/ What other tumors, except for prostate adenocarcinoma and lobular breast carcinoma, do you know to be positive for NKX3.1 IHC?
#IHCpath #breastpath
![Denkendes Gesicht 🤔](https://abs.twimg.com/emoji/v2/72x72/1f914.png)