Trends in Cancer Incidence in US Adolescents and Young Adults, 1973-2015, @JAMANetworkOpen

@AlyssaScott563 @StoltzfusKelsey @EricLehrer @DanTrifMD @LeilaTchelebi @PennStHershey

http://ja.ma/2JDKwSE 
http://bit.ly/2Vnwasp 
Trends in Cancer Incidence in US Adolescents and Young Adults, 1973-2015, @JAMANetworkOpen @AlyssaScott563 @StoltzfusKelsey @EricLehrer @DanTrifMD @LeilaTchelebi @PennStHershey http://ja.ma/2JDKwSE  http://bit.ly/2Vnwasp 
Trends in Cancer Incidence in US Adolescents and Young Adults, 1973-2015, @JAMANetworkOpen @AlyssaScott563 @StoltzfusKelsey @EricLehrer @DanTrifMD @LeilaTchelebi @PennStHershey http://ja.ma/2JDKwSE  http://bit.ly/2Vnwasp 
Trends in Cancer Incidence in US Adolescents and Young Adults, 1973-2015, @JAMANetworkOpen @AlyssaScott563 @StoltzfusKelsey @EricLehrer @DanTrifMD @LeilaTchelebi @PennStHershey http://ja.ma/2JDKwSE  http://bit.ly/2Vnwasp 
AYAs are individuals 15-39 years of age, have been defined by @theNCI as population w cancer distinct from children and older adults

https://www.cancer.gov/types/aya/research/ayao-august-2006.pdf
https://seer.cancer.gov/archive/publications/aya/aya_mono_complete.pdf
AYAs are individuals 15-39 years of age, have been defined by @theNCI as population w cancer distinct from children and older adults https://www.cancer.gov/types/aya/research/ayao-august-2006.pdf https://seer.cancer.gov/archive/publications/aya/aya_mono_complete.pdf
AYAs are individuals 15-39 years of age, have been defined by @theNCI as population w cancer distinct from children and older adults https://www.cancer.gov/types/aya/research/ayao-august-2006.pdf https://seer.cancer.gov/archive/publications/aya/aya_mono_complete.pdf
Cancer in AYAs has been a growing problem, and current treatment and management frameworks often fall in between pediatric and adult frameworks.

AYAs often note represented in cancer clinical trials. Work from our coauthor and mentor, Archie Bleyer:
https://pubmed.ncbi.nlm.nih.gov/11835231/ 
Cancer in AYAs has been a growing problem, and current treatment and management frameworks often fall in between pediatric and adult frameworks. AYAs often note represented in cancer clinical trials. Work from our coauthor and mentor, Archie Bleyer: https://pubmed.ncbi.nlm.nih.gov/11835231/ 
Cancer in AYAs has been a growing problem, and current treatment and management frameworks often fall in between pediatric and adult frameworks. AYAs often note represented in cancer clinical trials. Work from our coauthor and mentor, Archie Bleyer: https://pubmed.ncbi.nlm.nih.gov/11835231/ 
In the USA, clinical trial accrual at initial cancer diagnosis is only 0.1%, and it's even lower for AYAs https://twitter.com/NicholasZaorsky/status/1192853426603999232
In this work we assessed trends in incidence in AYAs. Overall, we found that the rate has increased by ~30% from 1973-2015
In this work we assessed trends in incidence in AYAs. Overall, we found that the rate has increased by ~30% from 1973-2015
In this work we assessed trends in incidence in AYAs. Overall, we found that the rate has increased by ~30% from 1973-2015
The majority of patients were female (59%) and white (80%). The proportion of patients diagnosed with cancer increased with increasing age at diagnosis. Carcinomas made up plurality of diagnoses, especially in older AYAs.
The majority of patients were female (59%) and white (80%). The proportion of patients diagnosed with cancer increased with increasing age at diagnosis. Carcinomas made up plurality of diagnoses, especially in older AYAs.
The majority of patients were female (59%) and white (80%). The proportion of patients diagnosed with cancer increased with increasing age at diagnosis. Carcinomas made up plurality of diagnoses, especially in older AYAs.
The majority of patients were female (59%) and white (80%). The proportion of patients diagnosed with cancer increased with increasing age at diagnosis. Carcinomas made up plurality of diagnoses, especially in older AYAs.
Work from @CAonline shows improvements in 5 year survival for AYA cancer patients.
However, survival improvement lags behind adults and peds, and the difference is more dramatic in USA vs Europe

https://pubmed.ncbi.nlm.nih.gov/31594027/ 
https://pubmed.ncbi.nlm.nih.gov/30124231/ 
Work from @CAonline shows improvements in 5 year survival for AYA cancer patients.However, survival improvement lags behind adults and peds, and the difference is more dramatic in USA vs Europe https://pubmed.ncbi.nlm.nih.gov/31594027/  https://pubmed.ncbi.nlm.nih.gov/30124231/ 
Work from @CAonline shows improvements in 5 year survival for AYA cancer patients.However, survival improvement lags behind adults and peds, and the difference is more dramatic in USA vs Europe https://pubmed.ncbi.nlm.nih.gov/31594027/  https://pubmed.ncbi.nlm.nih.gov/30124231/ 
Additionally, AYAs have unique social and developmental concerns.
@JournalCancer
And even for patients who are cured of disease, there may be long term sequelae of treatment, e.g., risk of heart disease
#cardiooncology / #oncocardiology
@NatureComms @Icro_Meattini
https://pubmed.ncbi.nlm.nih.gov/32332714/  https://twitter.com/NicholasZaorsky/status/1254518239243243522
Risk of stroke

work w @BradZachariaMD in @NatureComms
https://www.nature.com/articles/s41467-019-13120-6
http://ncbi.nlm.nih.gov/pubmed/31729378  https://twitter.com/NicholasZaorsky/status/1195700095037136898
And risk of suicide

@NatureComms
https://www.nature.com/articles/s41467-018-08170-1 https://twitter.com/NicholasZaorsky/status/1084788409338683394
Why do we see these trends in AYAs?
. @DavidSteensma sums it up well: https://twitter.com/DavidSteensma/status/1333880108030046216
Obesity, poor diet, lack of exercise appear to be a primary driver of several cancers, particularly colorectal ca

Data from Archie Bleyer
You can follow @NicholasZaorsky.
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