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Today in @ScienceMagazine by Venki Ramakrishnan Lab: Elongational stalling activates mitoribosome-associated quality control (with our small contribution of a model) Congrats! @_nirupa_desai @Hanting_Yang @vishy_chandra @razina_kazi @MRC_LMB @MRC_MBU | 1/5 https://science.sciencemag.org/content/370/6520/1105
This is a breakthrough in understanding mitochondrial translation: #cryoEM structures of mitoribosomes trapped in various translation stages & mitoribosome-linked quality control pathway (mtRQC) triggered by stalling during elongation to prevent aberrant translation | 2/5
The team used a genetically engineered human cells that lack the 2’-5’ phosphodiesterase 12 (PDE12). Inactivation of PDE12 leads to aberrant processing of tRNAs and mitoribosome stalling. Please see our paper by @Pearce55Sarah etal @FirthLab @eLife | 3/5 https://elifesciences.org/articles/27596
The study also explains the role a release factor homolog C12orf65 (mtRF-R), frequently implicated in #mitochondrialdisease, and a recently identified RNA-binding protein C6orf203 (MTRES1) @MolMet_KI @IIMCB_Poland @NAR_Open | 4/5
https://academic.oup.com/nar/article/47/14/7502/5521788
https://academic.oup.com/nar/article/47/17/9386/5545367
https://academic.oup.com/nar/article/47/14/7502/5521788
https://academic.oup.com/nar/article/47/17/9386/5545367
Previously reported ribosome biogenesis factors: MALSU1 (C7orf30), L0R8F8, and mt-ACP (mitochondrial acyl carrier protein) have a checkpoint role during in the mtRQC pathway @A_Amunts @alanbrownhms @NatureSMB
@NAR_Open | 5/5
https://www.nature.com/articles/nsmb.3464
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkr1282
@NAR_Open | 5/5
https://www.nature.com/articles/nsmb.3464
https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkr1282
