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Our systematic review and meta-analysis on #SARSCoV2, #SARSCoV & #MERSCoV viral load dynamics, duration of viral shedding & infectiousness out now in @LancetMicrobe 
@mugecevik @silverfoxdoc @CVRinfo @UofGlasgow @Infection_StAnd https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(20)30172-5/fulltext
@mugecevik @silverfoxdoc @CVRinfo @UofGlasgow @Infection_StAnd https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(20)30172-5/fulltext
Key findings:
- SARSCoV2 viral load in upper respiratory tract is highest within first 5 days of symptom onset.
- Mean duration of RNA shedding in URT was 17 days (95% CI, 15.5-18.6), maximum 83 days
- Shedding duration increases with age and illness severity
- SARSCoV2 viral load in upper respiratory tract is highest within first 5 days of symptom onset.
- Mean duration of RNA shedding in URT was 17 days (95% CI, 15.5-18.6), maximum 83 days
- Shedding duration increases with age and illness severity
- Viral load similar in symptomatic and asymptomatic individuals, but asymptomatic persons may shed virus for shorter duration
- No viable virus cultured beyond day 9
- Included studies mostly in hospitalised pts, therefore findings may not apply to persons with milder infections
- No viable virus cultured beyond day 9
- Included studies mostly in hospitalised pts, therefore findings may not apply to persons with milder infections
