n=240, 2-center "double-blind, randomized, placebo-controlled trial [...] in Sao Paulo, Brazil" of 1-time 200k IU D3 vs. placebo did not see a difference in timespan from randomization to discharge or death ("length of stay"). TBH, would've expected a small effect at least ... https://twitter.com/noordenstein/status/1328777626308255745
Before actually reading the paper: The timespan from randomization to discharge or death (~7 days) seems short, disease was severe already, they used cholecalciferol instead of calcifediol (which takes a while to be metabolized) ...
Probably not quite the study to convince me that "Vitamin D doesn't help", yet ... https://twitter.com/c19d3k2/status/1324401231532642304
Interesting thread by @saarwilf (auto-translate!) on why this particular experiment was _extremely_ unlikely to succeed from the get-go: https://twitter.com/saarwilf/status/1329156089900883968
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