Read on Twitter
Woohoo, our paper on functionally-informed fine-mapping and polygenic localization is out in @NatureGenet.
Here’s our evergreen explainer thread from last year: https://twitter.com/oweissb/status/1184915694040711168
See below what was added since then
https://www.nature.com/articles/s41588-020-00735-5
Here’s our evergreen explainer thread from last year: https://twitter.com/oweissb/status/1184915694040711168
See below what was added since then
https://www.nature.com/articles/s41588-020-00735-5
What we did since the preprint: We asked what happens when fine-mapping using external LD (e.g. 1000 genomes). Short answer: it doesn’t work
. This is a major problem, it's fine-mapping kryptonite.
See this thread I just wrote for a longer discussion: https://twitter.com/oweissb/status/1328393337343258639
. This is a major problem, it's fine-mapping kryptonite.See this thread I just wrote for a longer discussion: https://twitter.com/oweissb/status/1328393337343258639
Finally, this was a great team effort w/ Alkes Price, @FHormozdiari, @bennerstat, @julirsch, @StevenGazi, @Luke0connor, @MattiPirinen, and many other brilliant people not on Twitter (and requiring >280 chars). Thanks everybody!
P.S. I just posted two Twitter threads that reference each other, but disappointingly Twitter didn't run into an infinite loop and explode. Good job Twitter engineers!
