There is no evidence that TB2 destroyed S-300 or S-400 systems in Syria (we would know), and there is no evidence that Anka-S are in Libya. You also need to mention that plenty of TB2 were shot down by Pantsir-S1 (and probably Buk-M2E) in Syria and Libya.
https://www.rferl.org/a/technology-tactics-and-turkish-advice-lead-azerbaijan-to-victory-in-nagorno-karabakh/30949158.html

Modern Russian air defense systems like the Pantsir and Tor can shoot down TB2, but they can also be destroyed by TB2, particularly when operating alone. Training matters as do supporting assets (medium-range AD systems, electronic warfare, C2, radar, etc.)

The TB2 is a very effective system, particularly because it is cheap and its losses are sustainable, but if you send TB2 by themselves against an integrated air defense system like a Russian Ground Forces tank or motorized rifle division, they will get shot down.

Which is why Turkey would support them with Koral EW systems, Anka-S and other UCAVs/loitering munitions, F-16s, and other systems. So when we talk about these 1 on 1 engagements between Russian AD systems vs Turkish TB2 we only learn so much and we shouldn't exaggerate.