Cant wait to dig into the original research on children’s antibodies to #coronavirus potentially protecting them against #COVID19 . Any friends on #epitwitter or #MedTwitter have thoughts on it?

#Pediatrics #childhealth #infectiousdisease https://www.nytimes.com/2020/11/10/health/coronavirus-children.html#click=https://t.co/VqIvWvegY1
The Children Never Had the Coronavirus. So Why Did They Have Antibodies?

A provocative study suggests that certain colds may leave antibodies against the new coronavirus, perhaps explaining why children are more protected than adults.

https://www.nytimes.com/2020/11/10/health/coronavirus-children.html#click=https://t.co/VqIvWvegY1
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans https://science.sciencemag.org/content/early/2020/11/05/science.abe1107
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detect preexisting humoral immunity....

https://science.sciencemag.org/content/early/2020/11/05/science.abe1107
"given that HCoV-reactive antibodies are present in virtually all adults,rarity of SARS-CoV-2 S cross-reactivity(16 of 302; 5.29%),indicates addtl requirements,such as random B cell receptor repertoire focusing or frequency of HCoV infxn,rather than time since last HCoV infxn."3/
"The prevalence of SARS-CoV-2 S-reactive IgG antibodies peaked at 62% between 6 and 16 years of age (Fig. 2F), when HCoV seroconversion in this age group also peaks, and was significantly higher than in adults (P<0.00001, Fisher's exact test)." 4/
"Comparable neutralization of SARS-CoV-2 S pseudotypes was also observed w/ sera from SARS-CoV-2-uninfected adolescents.Moreover,the majority of sera from SARS-CoV-2-uninfected donors w/ flow cytometry-detectable cross-reactive Ab also neutralized authentic SARS-CoV-2 infection"5
"Together w/preexisting T cell & B cell memory,Ab cross-reactivity between seasonal HCoVs & SARS-CoV-2 may have important ramifications for natural infection." 6/
"Epidemiological studies of HCoV transmission suggest that cross-protective immunity is unlikely to be sterilizing or long-lasting,which is also supported by repeated reinfection." 7/
"Nevertheless, prior immunity induced by one HCoV can reduce the transmission of homologous and heterologous HCoVs, and ameliorate the symptoms where transmission is not prevented." 8/
Not finished with my re-read of this study but my first impression is that it is #BeautifulScience.

#COVID #BiologicPlausibility #ScienceMatters
9/
@DeannaMarie208 @ShawnteJamesMD @karenerrichetti @EpiEllie @SPER_News @Kidsdoc1Rick @alisadoc1 @DrCJohns @PedsGeekMD
You can follow @MAhealthforkids.
Tip: mention @twtextapp on a Twitter thread with the keyword “unroll” to get a link to it.

Latest Threads Unrolled:
Those who think consciousness raising & movement building are disconnected, or even a distraction from electoral politics have not paid attention to the history of social change.In this thread, we
Read more
The 2020s will be known as the Remote Work decadeA few predictions of what is likely to emerge[ a thread ] Third Space: Office and Working from Home will
Read more
1/29: Have you ever had a concept explained to you that helps frame complex issues you’ve been wrestling with and opens your eyes to new possibilities? A concept that I
Read more
By continuing to use the site, you are consenting to the use of cookies as explained in our Cookie Policy to improve your experience.