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Our paper was published today in Genes: Exploring the role of contactins across psychological, psychiatric and cardiometabolic traits within UK Biobank
https://mdpi.com/884954 What did we find? (1/7)
https://mdpi.com/884954 What did we find? (1/7)
We identified a novel genetic association between variation in CNTN1 and current smoking.
CNTN1 has previously been associated with neuropsychiatric (Parkinson's disease, Alzheimer's disease, bipolar disorder,
antidepressant response) but not behavioural traits. (2/7)
CNTN1 has previously been associated with neuropsychiatric (Parkinson's disease, Alzheimer's disease, bipolar disorder,
antidepressant response) but not behavioural traits. (2/7)
We also identified a novel genetic association between variation in CNTN2 and WHRadjBMI. CNTN2 has previously been associated with schizophrenia and WHR.
Patients with schizophrenia have a tendency towards abdominal obesity; our results suggest these are distinct signals. (3/7)
Patients with schizophrenia have a tendency towards abdominal obesity; our results suggest these are distinct signals. (3/7)
We identified two independent signals in CNTN4 for BMI. CNTN4 has previously been associated with BMI; that this is two independent signals is new. (4/7)
We also replicated associations previously found between CNTN5 and neuroticism, blood pressure and HbA1c: our identification that these signals are independent of each other is new. (5/7)
In summary, our evidence suggests the effects of these genes on psychological and cardiometabolic traits are likely distinct, with no shared mechanisms. (6/7)
Thanks to my supervisors and collaborators: @RJStrawbridge, @ProfDanielSmith, @amyferguson93, @keira_johnston, @Don_lyall, @laura_pidgeon and those not on Twitter
@uk_biobank participants
and @rcpsych for supporting me through the Psych Star scheme (7/7)
@uk_biobank participants
and @rcpsych for supporting me through the Psych Star scheme (7/7)
