Hey, @elonmusk! As an engineer turned chemist, then neuroscientist, now theoretical physicist, having touched a variety of distinct but increasingly overlapping fields of study, I wonder - have you considered the heat transfer problem that will result from overclocking the brain?

You probably have thought of this already, it is likely a surmountable problem with multiple possible clever solutions. The human body has implemented strategies for this issue that I believe are not currently recognized as what they are, usually interpreted as disease states.

I believe the depositing of amyloid plaques, seen now as purely a pathogenic process, is actually a suboptimal evolved strategy to counter CNS heating by absorbing the work of the heat into the amyloid protein, which is then denatured by the heat, leading to cooling of the area.

This is a suboptimal strategy because the denatured protein accumlates as plaques - the plaques having unintended harmful consequences as disease. This problem means the heat generated from multithreading brain processing via an implant will likely produce unexpected plaques.

A second disease state that I believe is actually an unrecognized natural but suboptimal heat transfer solution of the brain would be a CSF leak. Increased electrical activity leads to increased production of CSF to absorb the heat away from the neuronal body and into the fluid.

This is maybe a transient thing that is not a problem for a one off and short lived surge in brain electrical activity. Thinking intensely maybe results in a transient headache from the pressure increase. Sustained electrical activity over baseline results in sustained pressure.

Sustained increased intracranial hypertension from nontransient increases in electical activity eventually requires the fluid needing to drain to remove pressure from the brain stem. Anyone who has experienced a leak has felt the sensation of cold as the fluid drains.

The CSF feels cold draining from the base of your brain down the throat. It feels cold flowing out the skull fissures under your scalp down the back of your head. It feels cold b/c the leak exposes the heated CSF to surface area away from your brain, releasing heat by diffusion.

These are two examples of the current default mechanisms by which the human brain is able to dissipate undesirable heat increases from increased CNS electrical activity. Even if the increased electrical conduction is desirable, the undesirable reactions will require mitigation.