Biden says his motivation for the last 5 years has been to fulfil a promise he made to his son Beau after he was diagnosed with cancer. Here he is with Colbert a few months after Beau’s death.
The 2015 Biden/Colbert interview is probably the best one either man has done.

Colbert has an unusual empathy for Biden. In 1972 Biden’s wife and daughter died in a car crash. In 1974 Colbert’s father and two brothers died in a plane crash.

Here it is.
Part two
In 2017 they did a follow-up after Biden wrote a book about his grief.
(Reposted earlier thread to correct glaring typo)
During the first debate, Biden said Trump had insulted Beau with his private comments about troops. Trump ignored him and went after his other son Hunter. https://twitter.com/thehill/status/1311148099704950784
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