The majority of patients are < two years of age, with a median age of 12 months.

In the pre-antibiotic era, 5-10 % of cases of acute otitis media were complicated by acute mastoiditis
The mortality rate in the pre-antibiotic ear was 2/100000 population.

After antibiotics and pneumococcal vaccination (PCV-7), 0.002% of children with acute otitis media progress too acute coalescent mastoiditis with a mortality rate of less than 0.01 per 100000 population.
Uncomplicated patients with no significant medical history have had successful treatment as an outpatient with daily IV ceftriaxone with low complication rates

Uncomplicated inpatient cases are manageable w/ IV ax, high dose IV steroids, & myringotomy w tympanostomy tubes
If mastoiditis does not improve in 48 hours, mastoidectomy is indicated.

Streptococcus pyogenes correlated with the highest rate of complications at presentation, w/ nearly 50% of cases

S. aureus correlated with the highest rate of complications during hospitalization
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