If Republicans hold on to their leads in NC and AK, Democrats' only path to avoid a Mitch McConnell-run Senate would require winning both seats in Georgia. https://www.bloomberg.com/news/articles/2020-11-05/gop-shreds-democrats-senate-hopes-by-holding-on-in-key-states?srnd=politics-vp&sref=tmIR2vcd&utm_source=url_link

Unless Democrats pull off a comeback to win two more seats, Republicans could cripple Biden's agenda on issues ranging from climate change to health care to voting rights and slow-walk or kill his appointments.

McConnell's Republicans would hold the power over what happens if the Supreme Court strikes down all or part of the ACA, and Democrats would have no legislative recourse if a 6-3 SCOTUS tosses Roe as many Rs hope.

Going to be a lot of soul-searching by Democrats even if they somehow come back to win two seats.

Next chance for Dems, barring an unexpected Senate opening or a party-switching senator, would be the 2022 map, when there will again will be more R than D seats up.

A couple of battlegrounds: Pennsylvania and Wisconsin.

Murkowski is also on the ballot in 2022. Assuming she stays in the GOP, she faces either a brutal primary a la 2010, a potential general election anti-abortion indie challenger from the right a la 2016, etc.

Very awkward place for a senator in a 51-49 Senate to be.