Read on Twitter
THREAD: More data about PPIs and SARS-CoV-2 coming out. Is there a consistent association across studies? @statsepi @DrToddLee @supermarioelia @mikejohansenmd @ADAlthousePhD Increased prevalence of ARDS in those taking PPI at baseline: https://onlinelibrary.wiley.com/doi/full/10.1111/joim.13121
prior use of PPIs associated with higher rate of death in COVID-19 infected patients. https://www.medrxiv.org/content/10.1101/2020.09.10.20179135v1
Severe COVID-19 outcomes in Korea associated with PPI use https://gut.bmj.com/content/gutjnl/early/2020/07/30/gutjnl-2020-322248.full.pdf
Higher mortality from COVID-19 in prior PPI users https://www.medrxiv.org/content/10.1101/2020.07.12.20151084v1
PPIs(along with anti-psychotics, opioids, and polypharmacy) associated with severe COVID-19 in Scotland. https://www.medrxiv.org/content/10.1101/2020.07.23.20160747v1
While there were some weird demographic shifts in the original B. Spiegel study, the PPI finding appears to be holding up. I will continue to be spooked about internet surveys with incentives, & how they can be gamed, but repeated studies with different methods in diff.settings..
are backing up the association between pre-hospitalization PPI use (often with weak indications) and more severe COVID-19 cases. The great thing about medial science is that lots of people can do it, and many people are ready to challenge or refute your findings...
But in this case the primary finding seems to be holding up - PPI use prior to hospitalization (and likely prior to infection) is associated with worse outcomes in COVID-19. Nice to see a scientific hypothesis stress-tested across multiple countries and hold up. Science.
