Now watching @wccushman after @DrJMLuther laid the stage on whether chlorthalidone should be preferred over HCTZ

- VA trial https://jamanetwork.com/journals/jama/article-abstract/356138
- HDFP https://jamanetwork.com/journals/jama/article-abstract/367742
- SHEP https://jamanetwork.com/journals/jama/fullarticle/192921
- ALLHAT
- SPRINT
all had chlorthalidone
#Hypertension20
Effect of Treating Isolated Systolic Hypertension on the Risk of Developing Various Types and...

Context The Systolic Hypertension in the Elderly Program (SHEP) demonstrated that treating isolated systolic hypertension in older patients decreased incidence of total stroke, but whether all types...

https://jamanetwork.com/journals/jama/article-abstract/356138
Links
ALLHAT https://pubmed.ncbi.nlm.nih.gov/12479763/ 
SPRINT http://www.nephjc.com/sprint 

I would add that even HYVET was indapamide (more like CTD than HCTZ) https://www.nejm.org/doi/full/10.1056/NEJMoa0801369

#Hypertension20
Treatment of Hypertension in Patients 80 Years of Age or Older | NEJM

Original Article from The New England Journal of Medicine — Treatment of Hypertension in Patients 80 Years of Age or Older

https://pubmed.ncbi.nlm.nih.gov/12479763/
Still HCTZ remains most common - prob due to side effects (electrolytes) from 50 mg CTD

(would add https://www.acpjournals.org/doi/10.7326/0003-4819-158-6-201303190-00004)

Cost - In Ontario
HCTZ 25 mg = 1.6 cents
CTD 50 mg = 12.6 cents (so 12.5 mg = ~ 3 cents)

Also more fixed combos with HCTZ than CTD? #Hypertension20
Still HCTZ remains most common - prob due to side effects (electrolytes) from 50 mg CTD(would add https://www.acpjournals.org/doi/10.7326/0003-4819-158-6-201303190-00004)Cost - In OntarioHCTZ 25 mg = 1.6 centsCTD 50 mg = 12.6 cents (so 12.5 mg = ~ 3 cents) Also more fixed combos with HCTZ than CTD? #Hypertension20
Still HCTZ remains most common - prob due to side effects (electrolytes) from 50 mg CTD(would add https://www.acpjournals.org/doi/10.7326/0003-4819-158-6-201303190-00004)Cost - In OntarioHCTZ 25 mg = 1.6 centsCTD 50 mg = 12.6 cents (so 12.5 mg = ~ 3 cents) Also more fixed combos with HCTZ than CTD? #Hypertension20
There is a network MA (also shown by @DrJMLuther )

But 2 large ongoing head:head RCTs with CV outcomes

THIAZIDE https://clinicaltrials.gov/ct2/show/NCT02591628
and the
VA trial https://www.research.va.gov/programs/csp/597/default.cfm

#Hypertension20
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