Thread by @kis_lorand, Dear Tweeples what is your opinion about this adenocarcinoma? #pathology #IHCpath the [...]

Lorand Kis

kis_lorand

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Dear Tweeples what is your opinion about this adenocarcinoma?

#pathology #IHCpath

the beauty of such kind of interaction is that we quickly gather a nice list of ddx

Would the p53 IHC be of any help?

just a side comment: if I read "serous carcinoma" then I don't know if you mean uterine serous carcinoma or HGSC-high-grade serous carcinoma, the extrauterine type...just saying

last piece of the puzzle... looking further around on the slide one finds such areas

now you know it

Thanks everyone for your opinion and participation!!

No tricks here, bread and butter case of "carcinosarcoma"...MMMT or 3MT...fancy name for a high-grade carcinoma with sarcomatoid dedifferentiation ... note how the sarcomatoid component lights up in the p53 IHC

yesterday about the same time @DrGeeONE also shared a case of carcinosarcoma

https://twitter.com/DrGeeONE/status/1304178437817610242

https://twitter.com/DrGeeONE/status/1304178437817610242

some learning points:
- p16 can be positive in multiple high-grade tumors and it is not a sign of high-risk HPV infection... if in doubt HPV testing is the answer

this was a case of p16-positive clear cell carcinoma of the uterus https://twitter.com/kis_lorand/status/1085648882170621952