Check out this recent publication from the Estes Lab in @PNASNews using genetically modified #enteroids to study the interplay of host IFN responses and human #norovirus infection:
https://doi.org/10.1073/pnas.2010834117

@BCMFromtheLabs
1/4

Grad student Shih-Ching (Roy) Lin shows that GII.4 and GII.3 #norovirus strains are sensitive to exogenous IFN but only GII.3 infection is improved in IFN pathway-deficient #enteroids.
2/4

STAT1 knockout from #enteroids leads to increased GII.3 positive foci, increased clusters of GII.3-positive cells over time and a decreased TCID50 when compared to infection of WT enteroids.
3/4

This study adds to the growing list of differences in requirements for GII.3 and GII.4 human #noroviruses (e.g. bile acids are essential for GII.3 replication but not GII.4). These diffs may provide insight on why certain pathogenic strains are more widespread than others.
4/4