New paper out!

Interested in knowing how #CB1 receptors in #D1+ hippocampal #interneurons modulate to #synaptic #plasticity and #memory functions?

Check our latest study published in @CellReports (open access) where we address this question! (1/n) https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31031-7

First by using conditional mutagenesis we found that mice lacking CB1 receptors in D1-positive cells (D1-CB1-KO) displayed impairment in long-term, but not short-term, novel object recognition memory (NOR). (2/n)

Then we observed that cre-dependent re-expression of CB1 receptors in hippocampal, but not striatal, D1-positive cells rescued the NOR memory deficit. (3/n)

In addition we found that exposure to the NOR task could lead to a learning induced facilitation of in vivo hippocampal long-term potentiation ( #LTP) and we also observed that this phenomenon was absent in our mouse model. (4/n)

Finally we used #chemogenetic and #pharmacological approaches to show that both CB1 receptor-mediated NOR and associated LTP facilitation involved the local control of GABAergic inhibition in a D1-dependent manner. (5/n)

Altogether our study provides new evidence about the
CB1 receptor signaling and its functional link between hippocampal #dopaminergic and #GABAergic control of #synaptic #plasticity and #memory #consolidation. (6/n)

Happy to be part of this collaborative effort with @BGarcialab , @soria_edgar, all the remaining members of @MarsicanoLab and staff of the @NCMagendie !

And this closes my "PhD life chapter" at the @MarsicanoLab. Great lab, great mentorship and great people!

Last but not least mention to all the funding entities involved:
@Inserm
@Neuro_Bordeaux
@NCMagendie
@univbordeaux
@ERC_Research
@FRM_officiel
@AgenceRecherche
@Ikerbasque