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My favorite question to fellow researchers is "What's your all-time favorite paper?". Through the answer I can learn a lot about the person.
Let's try that on Twitter!
I'll begin. I've chosen with difficulty 5 papers I really liked.
The pic is a spoiler.
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Let's try that on Twitter!
I'll begin. I've chosen with difficulty 5 papers I really liked.
The pic is a spoiler.
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https://www.nature.com/articles/nature09941
Until reading this paper, I believed ES cells were only for 2D differentiation. The paper proposed the concept of SELF-ORGANIZATION of 3D tissue morphology. The data were also amazing: multiphoton imaging, elasticity measurement, simulation...Too good!
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Until reading this paper, I believed ES cells were only for 2D differentiation. The paper proposed the concept of SELF-ORGANIZATION of 3D tissue morphology. The data were also amazing: multiphoton imaging, elasticity measurement, simulation...Too good!
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https://www.nature.com/articles/nature03461
In 2005, I first encountered SYNTHETIC BIOLOGY. The idea of making and even designing biological functions was super fresh to me!
The synthetic bullseye pattern in E coli also embodies the positional information concept of developmental biology.
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In 2005, I first encountered SYNTHETIC BIOLOGY. The idea of making and even designing biological functions was super fresh to me!
The synthetic bullseye pattern in E coli also embodies the positional information concept of developmental biology.
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https://science.sciencemag.org/content/308/5720/414.long
Masterpiece of in vitro RECONSTITUTION. Just 3 genes can reconstitute a 24h rhythm. The reconstitution not only proved the sufficiency but also brought discoveries: no transcription required for the oscillation; even temperature compensation shown.
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Masterpiece of in vitro RECONSTITUTION. Just 3 genes can reconstitute a 24h rhythm. The reconstitution not only proved the sufficiency but also brought discoveries: no transcription required for the oscillation; even temperature compensation shown.
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https://www.cell.com/cell/fulltext/S0092-8674(05)00115-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867405001157%3Fshowall%3Dtrue
This optogenetics paper in 2005 made me realize the huge potential of MANIPULATING biological functions. I still remember the shock of seeing the movie where a headless fly flew off upon photo-stimulation.
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This optogenetics paper in 2005 made me realize the huge potential of MANIPULATING biological functions. I still remember the shock of seeing the movie where a headless fly flew off upon photo-stimulation.
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https://www.nature.com/articles/nature05014
I was struck by the power of MATHEMATICAL MODEL in this paper @MGStowers. A simple Markov model beautifully explained the distribution of polygonal cell shapes in epithelia, including the dominance of hexagons. The paper that motivated me to learn math.
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I was struck by the power of MATHEMATICAL MODEL in this paper @MGStowers. A simple Markov model beautifully explained the distribution of polygonal cell shapes in epithelia, including the dominance of hexagons. The paper that motivated me to learn math.
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If you liked these tweets, please introduce your all-time favorite paper with the hashtag #AllTimeFavoritePaper. I'm curious about what papers have shaped you and why you loved them.
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